{ "netuid": 25, "slug": "mainframe", "name": "Mainframe", "symbol": "\u05d0", "description": "Powering decentralized science on Bittensor", "priceTao": 0.004650605, "priceUsd": 1.1768407375011067, "athUsd": 1.1768407375011067, "change24h": 0.31470993946309495, "change7d": -4.5103837094963675, "change30d": -1.5941368738471877, "change90d": 0.0, "marketCapUsd": 5165970.886685588, "volume24hUsd": 12242.837244185675, "rootProp": 0.1597979845992165, "liquidityUsd": 5518376.778872857, "alphaStaked": 2044980.065640836, "activeMiners": 1, "activeValidators": 14, "emissionPct": 0.004898422992835427, "emissionPerDayTao": 1.0, "registrationCost": 0.0, "pruningRank": 52, "immunityRemaining": 21480, "sentiment": "Neutral", "githubRepo": "https://github.com/macrocosm-os/mainframe", "subnetUrl": "https://macrocosmos.ai/sn25", "scorecard": { "adoption": { "label": "weak", "score": 26, "reasons": [ { "tone": "neutral", "label": "Stars", "value": "31", "weight": null }, { "tone": "positive", "label": "Contributors", "value": "17", "weight": null }, { "tone": "neutral", "label": "24h volume", "value": "$12,243", "weight": null }, { "tone": "neutral", "label": "Validators", "value": "14", "weight": null }, { "tone": "neutral", "label": "Bus factor", "value": "Top contributor: 51%", "weight": null }, { "tone": "neutral", "label": "LLM blend", "value": "heuristic=29 \u00d7 0.6 + llm=22 \u00d7 0.4", "weight": null } ] }, "shipSpeed": { "label": "weak", "score": 7, "reasons": [ { "tone": "neutral", "label": "Commits 30d", "value": "0", "weight": null }, { "tone": "neutral", "label": "Merged PRs 30d", "value": "0", "weight": null }, { "tone": "neutral", "label": "Releases 12m", "value": "1", "weight": null }, { "tone": "negative", "label": "Latest push", "value": "2025-09-29T14:26:59Z", "weight": null }, { "tone": "neutral", "label": "Momentum", "value": "no history (0/30d vs 0/mo avg)", "weight": null }, { "tone": "neutral", "label": "LLM blend", "value": "heuristic=7 \u00d7 0.6 + llm=8 \u00d7 0.4", "weight": null } ] }, "updatedAt": "2026-04-29T20:41:08.731469+00:00", "confidence": 0.82, "usefulness": { "label": "watch", "score": 41, "reasons": [ { "tone": "neutral", "label": "Durable keywords", "value": "1 matched", "weight": null }, { "tone": "positive", "label": "Commodity risk", "value": "0 matched", "weight": null }, { "tone": "neutral", "label": "Subnet traction", "value": "1/30", "weight": null }, { "tone": "neutral", "label": "LLM blend", "value": "heuristic=41 \u00d7 0.6 + llm=42 \u00d7 0.4", "weight": null } ] }, "codeQuality": { "label": "weak", "score": 31, "reasons": [ { "tone": "negative", "label": "CI", "value": "Missing", "weight": null }, { "tone": "positive", "label": "Tests", "value": "1 dir(s), framework config", "weight": null }, { "tone": "positive", "label": "Docs", "value": "Basic (600 chars)", "weight": null }, { "tone": "negative", "label": "Dep mgmt", "value": "None", "weight": null }, { "tone": "negative", "label": "PR reviews", "value": "1.5 avg, 60% self-merge", "weight": null }, { "tone": "neutral", "label": "Commit quality", "value": "0% conventional", "weight": null }, { "tone": "neutral", "label": "Security hygiene", "value": "No SECURITY.md", "weight": null }, { "tone": "neutral", "label": "LLM blend", "value": "heuristic=25 \u00d7 0.6 + llm=40 \u00d7 0.4", "weight": null } ] } }, "marketScore": 11.0, "githubScore": 34.0, "aiScore": 30.0, "masterScore": 29.0, "masterRating": "D", "lastUpdatedAt": "2026-04-29T20:21:48Z", "isStale": false, "masterScorePrev": 23.0, "purpose": { "title": "Mainframe", "source": "llm", "confidence": 0.72, "shortSummary": "Mainframe (SN25) targets decentralized scientific compute on Bittensor, with topics including molecular dynamics and density functional theory (DFT). However, with only 1 active miner, 0 commits in the last 90 days, and $12K daily volume, the network is effectively dormant despite its conceptually differentiated niche. Development appears stalled and on-chain activity is critically thin." }, "analysis": { "risks": [ "Only 1 active miner recorded \u2014 the compute network is functionally non-operational; a DeSci subnet with no miners produces no scientific value", "Zero commits and zero merged PRs across both the 30-day and 90-day windows, combined with commit message quality score of 0.0 \u2014 development is completely stalled with no measurable shipping velocity" ], "score": 30, "summary": "Mainframe (SN25) targets decentralized scientific compute on Bittensor, with topics including molecular dynamics and density functional theory (DFT). However, with only 1 active miner, 0 commits in the last 90 days, and $12K daily volume, the network is effectively dormant despite its conceptually differentiated niche. Development appears stalled and on-chain activity is critically thin.", "provider": "cascade:sonnet", "expiresAt": "2026-05-29T20:31:28.334692+00:00", "strengths": [ "Targets a differentiated niche \u2014 molecular dynamics and DFT are legitimate high-value scientific domains with real research demand, not commodity AI wrappers", "17 contributors and 14 active validators provide a non-trivial organizational footprint relative to the subnet's size", "Repo includes tests, a license, and docs \u2014 baseline hygiene is present, and avg 1.5 reviews per PR suggests some code review culture" ], "updatedAt": "2026-04-29T20:31:28.334692+00:00", "durability": "weak", "recommendation": "Do not allocate until at least 10+ active miners appear and the commit cadence resumes; the concept is sound but the network has no live compute and no active development to justify current market cap.", "dimensionScores": { "adoption": 22, "shipSpeed": 8, "usefulness": 42, "codeQuality": 40 } }, "repoCoverageStatus": "covered", "image": "https://www.macrocosmos.ai/favicon.ico", "repos": [ { "netuid": 25, "repoKind": "primary", "provider": "github", "owner": "macrocosm-os", "name": "mainframe", "url": "https://github.com/macrocosm-os/mainframe", "source": "registry", "isArchived": false, "isFork": false } ], "repoSnapshots": [ { "fullName": "macrocosm-os/mainframe", "description": "Generalized Scientific Compute on BIttensor", "homepageUrl": "https://www.macrocosmos.ai/sn25", "defaultBranch": "main", "stars": 31, "forks": 23, "watchers": 4, "contributors": 17, "commits30d": 0, "commits90d": 0, "mergedPrs30d": 0, "mergedPrs90d": 0, "releases12m": 1, "openIssues": 22, "closedIssues30d": 0, "languages": [ { "name": "Python", "percentage": 95.0 }, { "name": "Shell", "percentage": 4.9 }, { "name": "JavaScript", "percentage": 0.1 } ], "topics": [ "bittensor", "crypto", "decentralized", "dft", "molecular-dynamics" ], "rootSignals": { "hasCi": false, "hasTests": true, "hasLintConfig": false, "hasFormatterConfig": false, "hasTypeScript": false, "hasLicense": true, "hasSecurityPolicy": false, "hasDocs": true, "hasDocker": false, "hasDependabot": false, "hasRenovate": false, "rootEntries": [ ".circleci", ".env.example", ".gitignore", "LICENSE", "README.md", "assets", "contrib", "documentation", "folding", "folding_api", "install.sh", "install_rqlite.sh", "min_compute.yml", "neurons", "pdb_ids.pkl", "pm2_configs", "poetry.lock", "pyproject.toml", "run_autoprocess.sh", "scripts", "setup.py", "tests" ] }, "readmeExcerpt": "
\"mainframe-official\"
*inspiration from owl_posting https://x.com/owl_posting *
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"github_contributor", "confidence": 0.807, "profile_image_url": "https://pbs.twimg.com/profile_images/817074782793568256/gwYE6Ucm_normal.jpg" }, { "handle": "owl_posting", "role": "project", "label": null, "source": "github_readme", "confidence": 0.7, "profile_image_url": "https://pbs.twimg.com/profile_images/1818121449829191680/nzZmQT_h_normal.jpg" } ], "recentTweets": [ { "tweet_id": "2049470823711309996", "handle": "owl_posting", "text": "it\u2019s time to read the article anon https://t.co/yfviBs9iLb", "created_at": "2026-04-29T09:48:16-03:00", "likes": 29, "retweets": 1, "replies": 2, "views": 2757, "is_retweet": false, "is_reply": false, "media_type": null }, { "tweet_id": "2049202031911415998", "handle": "owl_posting", "text": "RT @WoodingtonBen: Another great piece from @owl_posting, a truly excellent history/state-of-play review for anyone wanting to understand b\u2026", "created_at": "2026-04-28T16:00:11-03:00", "likes": 11, "retweets": 1, "replies": 0, "views": 2448, "is_retweet": false, "is_reply": false, "media_type": null }, { "tweet_id": "2049074236237459914", "handle": "owl_posting", "text": "RT @btnaughton: Biotech CVRs/warrants are rare but fascinating. Trading on specific drugs and outcomes really appeals...\n\nThis is GCVRZ: ht\u2026", "created_at": "2026-04-28T07:32:22-03:00", "likes": 12, "retweets": 1, "replies": 0, "views": 2609, "is_retweet": false, "is_reply": false, "media_type": null }, { "tweet_id": "2048917357549036001", "handle": "owl_posting", "text": "RT @p_maverick_b: @arram As usual, @owl_posting just happened to write a deep dive today on financialization in biotech that's very insight\u2026", "created_at": "2026-04-27T21:08:59-03:00", "likes": 27, "retweets": 3, "replies": 1, "views": 5097, "is_retweet": false, "is_reply": false, "media_type": null }, { "tweet_id": "2048880409274990674", "handle": "owl_posting", "text": "RT @rlacombe: Intro hitting hard. \n\n(From the excellent @owl_posting) https://t.co/vGKlS7bWZ9", "created_at": "2026-04-27T18:42:10-03:00", "likes": 116, "retweets": 14, "replies": 5, "views": 24560, "is_retweet": false, "is_reply": false, "media_type": null }, { "tweet_id": "2048844566279721099", "handle": "owl_posting", "text": "RT @BenjaminGVincen: Fantastic essay. Looking forward to the follow-up on effects of biotech in China", "created_at": "2026-04-27T16:19:44-03:00", "likes": 10, "retweets": 3, "replies": 1, "views": 2952, "is_retweet": false, "is_reply": false, "media_type": null }, { "tweet_id": "2048821220661948521", "handle": "owl_posting", "text": "RT @c_m_ponce: I\u2019ve seen enough, put this guy in the hall of fame for accessible writing on pharma economics, right next to Jack Scannell &\u2026", "created_at": "2026-04-27T14:46:58-03:00", "likes": 115, "retweets": 5, "replies": 1, "views": 22731, "is_retweet": false, "is_reply": false, "media_type": null }, { "tweet_id": "2048793449306968199", "handle": "owl_posting", "text": "the buying and selling of drug royalties is interesting. but something i didnt mention here (and seems understudied) is how much universities are systematically underpricing their work. because they almost certainly are, given how bad tech transfer offices are https://t.co/NbfH5sV56n", "created_at": "2026-04-27T12:56:37-03:00", "likes": 80, "retweets": 6, "replies": 5, "views": 6557, "is_retweet": false, "is_reply": false, "media_type": null }, { "tweet_id": "2048751371566879055", "handle": "owl_posting", "text": "Curious cases of financial engineering in biotech\n7k words, 32 minutes reading time\n\nlink: https://t.co/gmPe7Dn5H3\n\nthe inflation-adjusted cost of developing a new drug roughly doubles every nine years. this is obviously horrible, but at least its had one interesting consequence: financiers, faced with an industry this structurally broken, have had room to exercise a kind of radical creativity\n\nthe essay is about that creativity, which i'll loosely call 'financial engineering'. i walk through five examples, a case study for each, and why they're worth thinking about. at the end, i ask what the aggregate effect of all this creativity is, and whether it's worrying for what biotech decides to value in the upcoming years", "created_at": "2026-04-27T10:09:25-03:00", "likes": 306, "retweets": 33, "replies": 10, "views": 62674, "is_retweet": false, "is_reply": false, "media_type": null }, { "tweet_id": "2048425514981863665", "handle": "owl_posting", "text": "this was the first podcast i ever traveled by train to do\n\njust about a year later, ill be filming my first podcast that i will travel by flight to do (in ~2 weeks)\n\npodcasting is very stressful. but it\u2019s the right thing to do", "created_at": "2026-04-26T12:34:35-03:00", "likes": 43, "retweets": 3, "replies": 2, "views": 4562, "is_retweet": false, "is_reply": false, "media_type": null }, { "tweet_id": "2048192142552576284", "handle": "owl_posting", "text": "i am moving to san francisco https://t.co/BQKZiLw7dK", "created_at": "2026-04-25T21:07:15-03:00", "likes": 384, "retweets": 7, "replies": 31, "views": 16333, "is_retweet": false, "is_reply": false, "media_type": null }, { "tweet_id": "2047786720582570381", "handle": "owl_posting", "text": "https://t.co/hMRHcwEGLN", "created_at": "2026-04-24T18:16:14-03:00", "likes": 11, "retweets": 3, "replies": 0, "views": 1196, "is_retweet": false, "is_reply": false, "media_type": null }, { "tweet_id": "2047401633303417015", "handle": "owl_posting", "text": "it is good to be enamored by lab robotics, but it is also good to have a clear vision of what better lab robotics actually buys you. it certainly buys you something, but what is that something, and how useful is it exactly?\n\nhttps://t.co/tZe1sEoaxG", "created_at": "2026-04-23T16:46:02-03:00", "likes": 74, "retweets": 13, "replies": 2, "views": 8280, "is_retweet": false, "is_reply": false, "media_type": null }, { "tweet_id": "2047154826887172151", "handle": "owl_posting", "text": "how do people submit things to the Serious Literary Magazines\n\ni have an essay about a (failed) cancer drug that i think is fun and readable to a more general audience. but the Atlantic's submission page has a picture of a creepypasta'd Tom from Tom And Jerry and nothing else", "created_at": "2026-04-23T00:25:19-03:00", "likes": 102, "retweets": 4, "replies": 6, "views": 10453, "is_retweet": false, "is_reply": false, "media_type": null }, { "tweet_id": "2047017927690330539", "handle": "owl_posting", "text": "genuinely crazy what type of content gets to the top 50 of hacker news. completely unpredictable https://t.co/5cWCzsuLJq", "created_at": "2026-04-22T15:21:20-03:00", "likes": 125, "retweets": 5, "replies": 2, "views": 22918, "is_retweet": false, "is_reply": false, "media_type": null }, { "tweet_id": "2046715316026143192", "handle": "owl_posting", "text": "RT @stephenra: Fascinating interview from @owl_posting in a space that I feel is often overlooked or underappreciated.", "created_at": "2026-04-21T19:18:52-03:00", "likes": 21, "retweets": 2, "replies": 1, "views": 6299, "is_retweet": false, "is_reply": false, "media_type": null }, { "tweet_id": "2046666408130421075", "handle": "owl_posting", "text": "RT @AllThingsApx: OK, this is super cool - watch this at the airport on the way to @iclr_conf if you care about AI and biology. \n\nYou won't\u2026", "created_at": "2026-04-21T16:04:31-03:00", "likes": 9, "retweets": 2, "replies": 0, "views": 1600, "is_retweet": false, "is_reply": false, "media_type": null }, { "tweet_id": "2046651092855857530", "handle": "owl_posting", "text": "people often complain about paywalls and 'how it cuts down distribution, so its dumb to do it', but, by virtue of my substack being recommended whenever you subscribe to Core Memory, i can vaguely tell when ashlee has produced a banger, and so i feel pretty confident that this episode has netted him multiples more new subscribers than most of his free stuff. the purpose of a paywall is to make money, yes, but the much more important part of it is that people equate money with value. free is suspicious. paid is suspicious too, but you at least start the internal 'is this worth it?' conversation that you otherwise would've entirely ignored\n\nfairly, this is obviously kind of a dark pattern, and that in the ideal world, substack would allow you to do one-off payments rather than automatically do recurring payments. this is fair. but there's a reason that virtually zero news outlets run themselves that way: it does not work. the alternative to you subsidizing everything rather than a subset is that the 'everything' simply does not exist at all\n\ngood episode, you should listen to it\n\nhttps://t.co/BYJlA2RvAT", "created_at": "2026-04-21T15:03:40-03:00", "likes": 18, "retweets": 1, "replies": 0, "views": 3995, "is_retweet": false, "is_reply": false, "media_type": null }, { "tweet_id": "2046612346554999062", "handle": "owl_posting", "text": "Walk me through a media optimization workflow\n\n\"The best way to think about biologics manufacturing is to think about it as high precision manufacturing, closer to semiconductor manufacturing. That's really the reason why Samsung Biologics is in the position that they are \u2014 because they took what they learned in terms of process control and brought that over. The reason that Fujifilm is a large manufacturer is because they took chemical process engineering and brought it over. Now, these were not biological companies, right? They are industrial manufacturing companies.\"", "created_at": "2026-04-21T12:29:42-03:00", "likes": 57, "retweets": 7, "replies": 2, "views": 11951, "is_retweet": false, "is_reply": false, "media_type": null }, { "tweet_id": "2046408451597705243", "handle": "owl_posting", "text": "RT @Sterling_Hooten: Autonomous labs are inevitable. Right now it's stuck at the petri-dish level. @jrkelly is killing the bench top-down,\u2026", "created_at": "2026-04-20T22:59:29-03:00", "likes": 85, "retweets": 8, "replies": 3, "views": 12824, "is_retweet": false, "is_reply": false, "media_type": null } ] }