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      "text": "RT @proofoftalk: Micaela Bazo @micaelabazo is the CEO and co-founder of Metanova Labs @metanova_labs, a crypto-native biotech building NOVA\u2026",
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      "text": "NOVA Nanobodies competition launched 2 weeks ago.\n\n3,000 submissions. Data got better fast!\n\nHow submissions improved over time:\n\n- Binding confidence: up ~3x from first submission to last\n- Structural fit: uncertainty at the interface dropped by nearly half\n- Hydrogen bonds: grew steadily across all 3,000 designs with no sign of plateauing\n- Buried surface contact: increased modestly but steadily, with later designs gripping the target across a larger area\n- Salt bridges: flat early, then accelerated sharply after submission ~2,000\n\nThe target: PD-L1, the protein cancer uses to hide from your immune system. Blocking it is the mechanism behind some of the most successful cancer drugs ever approved like Keytruda, Opdivo, Tecentriq.\n\nNanobodies are a next-generation format: smaller, cheaper to manufacture, and better at penetrating tumors than conventional antibodies. A well-designed anti-PD-L1 nanobody could become a more accessible cancer immunotherapy, or a building block for next-generation bispecific drugs that hit 2 targets at once.\n\nThis happened permissionlessly. \nNo central lab. \nJust an open incentive mechanism rewarding the best work.\n\n#Bittensor #SN68 #DeSci #DrugDiscovery #Cancer #Nanobodies",
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      "text": "Direct payouts are now live on NOVA Compound\n\nWinning submissions get paid no matter what happens to the UID during evaluation\n\n- Cleaner incentives\n- Fairer rewards\n- Less edge-case gaming https://t.co/Tkg1nWW6bQ",
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      "text": "RT @micaelabazo: s/o to @metanova_labs team for successfully coordinating real breakthroughs in AI drug discovery techniques\n\nincentive mec\u2026",
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      "text": "RT @micaelabazo: the TAM is real\n\nrecent moves by AI giants confirm that drug development isn\u2019t just another vertical \n\nit\u2019s the final fron\u2026",
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      "text": "NOVA Nanobodies competition is now live on the dashboard\n\nExplore the latest submissions: \nhttps://t.co/wBF8NBh4WX\n\n#Bittensor #SN68 #Nanobodies #DeSci #DeAI https://t.co/o3IU9qlJMD",
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      "text": "RT @OAlsta: Awesome update from @micaelabazo about @metanova_labs on $TAO, hosted by @markjeffrey. Huge progress over the past year!!\n\nBut\u2026",
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      "text": "RT @markjeffrey: Hash Rate - Ep. 165: Metanova - Subnet 68\n\ud83e\uddd9 Guest: @micaelabazo of @metanova_labs \n\n00:00 Introduction to Metanova and Hel\u2026",
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      "text": "RT @micaelabazo: exploits are a feature, not a bug.\n\nresilient systems of all kinds are built through exposure to stressors that lead to th\u2026",
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      "text": "RT @Yalotein: Psyched to see nanobodies now live on NOVA.\n\nWith NOVA Compound now spanning both small molecules and nanobodies, this is a m\u2026",
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      "text": "NOVA nanobodies competition is now live!\n\nNOVA Compound now spans 2 therapeutic modalities.\n\nMiners will be submitting both small molecules + nanobodies in every challenge.\n\nTop 50 nanobody submissions will be validated in the wet lab in partnership with @Yalotein \n\nNOVA is the first of its kind. Still the only one and scaling fast.\n\n#Bittensor #SN68 #DrugDiscovery #DeSci #DeAI",
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      "text": "Join us in Montreal \nSep 28-29\n\nEarly bird tickets are on sale now",
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      "text": "We came to Bittensor to build NOVA because it\u2019s the best network to carry out our mission.\n\nThere is no comparison.\n\nThere would be no NOVA without this community and we\u2019re grateful to everyone who helped make this possible.\n\nOur conviction remains unchanged.\n\nWe\u2019re here to build life-changing technology, powered by aligned incentives and open participation.\n\nOnwards and upwards. \n\nNothing can stop us.",
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      "text": "Nanobody competition goes live on NOVA Compound this Monday\n\nThe first decentralized virtual screening platform in the world is now adding its second therapeutic modality.\n\nThe Medical Advantage:   \n- Small molecules \u2192 oral, chronic therapies\n- Nanobodies \u2192 high specificity for \u201cundruggable\u201d targets\n\nThe Business Edge:   \n- Diversification: Blockbuster pills & high-margin drugs.\n- Speed: Parallel screening for faster leads.\n- Value: A next-gen platform (not a one-trick company) making us a prime partner for all.\n\nCode + docs are now available on our repo: https://t.co/5G6pKFdci1\n\nFeed it to your agents and read it too. Get ready to mine our new incentive mechanism.\n\nThis expansion into nanobody screenings is part of our partnership with @Yalotein\n\nTop 50 winning submissions will be selected for wet lab validation.  \n\n#Bittensor #SN68 #DrugDiscovery #DeAI #DeSci #Nanobodies #Biologics",
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      "handle": "metanova_labs",
      "text": "Learn more about @pennapdr @urdof07 growing agent fleet supporting NOVA's ops, discord, chemical analysis of submissions, and patent-molecule autoresearch \ud83d\udc47\n\n#Bittensor #SN68",
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      "text": "Next-gen human enhancement: muscle, cognition, mood \u2014 beyond GLP-1s\n\n@metanova_labs\n\nhttps://t.co/wBF8NBh4WX https://t.co/Heiw5Tc2mR",
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      "text": "RT @0xSammy: Great conversation, well worth listening to this episode of the @supercyclepod \n\nSubnet 68 (Metanova) compresses the typical d\u2026",
      "created_at": "2026-04-02T15:01:10-03:00",
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      "handle": "metanova_labs",
      "text": "RT @micaelabazo: on @bittensor and @metanova_labs \ud83d\udc47",
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      "text": "First NOVA Blueprint bounty paid out since upgrade\n\nNew winner:\n\n1. Learned which reactants actually produce signal\n2. Biased generation toward what works\n3. Increased memory (150 \u2192 500)\n4. Coordinated global search (DJA) with local search (tabu)\n5. Added anti-plateau dynamics\n\nNet result:\nA more adaptive, memory-rich, and directed search process.\n\nBlueprint is working as intended:\nOptimizers themselves are evolving under competition\n\n\ud83d\udd17 https://t.co/EevQyfZEDZ\n\n#Bittensor #SN68 #DrugDiscovery",
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      "text": "RT @twistartups: You don't need a biology degree to help find new drugs anymore.\n\n@metanova_labs turned drug discovery into a search and op\u2026",
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